Scientific Articles

1. von Eyben FE, Larsen V, Pedersen H. 5-fluorouracil (NSC-19893), DTIC (NSC-45388), BCNU (NSC-409962), and vincristine (NSC-67574) in advanced colorectalcarcinoma. Cancer Treatm Rep 1976;60:29-32
Negated additonal effect from combination chemotherapy of colorectal carcinoma.
2. Mattsson W, Arwidi Å, von Eyben F, Lindholm C-E. Phase II study of combined vincristine, adriamycin, cyclophosphamide, and methotrexate with citrovorum rescue in metastatic breast cancer. Cancer Treatm Rep 1977;61:1527-31
3. Mattsson W, von Eyben F, Turesson I, Wählby S. Prednimustine (NSC-134087, Leo 1031) treatment of lymphocytic and lymphocytic-histiocytic lymphomas. Cancer 1978;41:112-6. (early report on a promising new drug)
4. von Eyben FE. Biochemical markers in advanced testicular tumors. Serum lactate dehydrogenase, urinary chorionic gonadotropin and total urinary estrogens. Cancer 1978;41:648-52(cited more than 150 times. First article to describe the association between S-LDH and tumor burden in patients with testicular germ cell tumors and the relation between raised S-LDH and poor prognosis. As a repeat findings S-LDH is part of the TNM classification of 1997).
5. von Eyben F, Skyhøj Olsen T. Cytomegalovirus pneumonia after treatment with melphalan and prednisone. Report of a case. Acta Med Scand 1978;203:333-5
6. von Eyben FE, Mattsson W, Tropé C. Phase II study ofPrednimustine (NSC-134087, EORTC 1502) in advancedlymphocytic and lymphocytic-histiocytic lymphomas.Current chemotherapy. Proc 10th Int Congress Chemotherapy 1978;Vol II:1273-4
7. von Eyben F, Mattsson W, Glifberg I, Lindholm C-E. Chemotherapy of advanced transitional cell carcinoma of the renal pelvis: Report of 3 cases treated with vinblastine and chloroethyl-cyclohexyl-nitrosourea. J Urol 1979;121:367-8
8. Mattsson W, Arwidi Å, von Eyben F, Lindholm C-E. Combination chemotherapy in advanced postmenopausal mammary carcinoma. A comparison between VAC and VACM therapy. Acta Radiol 1979,18:431-44
9. Krabbe S, Skakkebæk NE, Berthelsen JG, von Eyben F, Volsted P, Mauritzen K, Eldrup P, Nielsen AH. High incidence of undetected neoplasia in maldescended testes. Lancet 1979;i:999-1000(cited more than 150 times - 4 subclinical tumors found in 75 screened men. First study to characterize a clinical stage in testicular germ cell tumors, where post-orchiectomy therapy is not indicated and first study to screen patients with maldescended testes for testicular germ cell tumors. Now surveillance only therapy is an established therapy for stage I nonseminomatous testicular tumors in most institutions).
10. von Eyben F, Hellekant C, Mattsson W, Ljungquist U, Jonsson K. Mitomycin C in advanced gallbladder cancer. Acta Radiol (Oncol) 1980;19:81-4
11. von Eyben F, Krabbe S, Skakkebæk NE. Alpha-foetoprotein and human chorionic gonadotropin in men with maldescended testes. Br J Cancer 1980;42:156-7
12. von Eyben F, Mikulowski P, Busch C. Microinvasive germ cell tumors of the testis. J Urol 1981;126:842-4
(describes a new term for a pathological stage between carcinoma in situ of the testis and macroscopically overt tumors. The term is generally accepted term for this phase in tumor progression).
13. von Eyben FE, Bruze M, Eksborg S, Mattsson W, Jonsson K. Toxic epidermal injury following intraarterial adriamycin treatment. Cancer 1980;48:1535-8. (new side effect of doxorubicin).
14. von Eyben FE, Arends J. Suppression of the response of normal lymphocytes by serum from patients with testicular germ cell tumors. Am J Reprod Immunol 1983;4:5-10.
15. Mattsson W, von Eyben F, Hallsten L, Bjelkengren G. A phase II study of combined 5-fluorouracil and mitomycin C in advanced breast cancer. Cancer 1982;49:217-20(first routine use of mitomycin for breast cancer in Europe. The regimen has been standard second chemotherapy for breast cancer in women for most Nordic oncology units for more than a decade).
16. von Eyben FE, Arwidi Å, Hellekant C, Jonsson K, Lindahl SÅ, Mattsson W, Tennvall L. Vincristine, adriamycin, cyclophosphamide and etoposide (VP 16-213) in small-cell anaplastic carcinoma of the lung. Cancer Chemother Pharmacol 1982;7:195-7
17. von Eyben FE. Phase II study of vindesine in patients with advanced breast carcinoma. Drugs Exptl Clin Res 1982;8:547-51 (negated effect from vindesine in breast carcinoma).
18. von Eyben FE, Skude G, Fosså SD, Klepp O, Børmer O. Serum lactate dehydrogenase (S-LDH) and S-LDH isoenzymes in patients with testicular germ cell tumors. MGG 1983;189:326-33
19. von Eyben FE, Tropé C, Ljungberg O, Alm P, Wennerberg J, Gullberg B. Histologic pattern and growth in two human testis cancers before and after transplantation to nude mice. Cancer 1982;50:2845-53(first paper to describe the Gompertzian growth pattern of a human solid tumor - both in the host and after transplantation to nude mice).
20. Tropé C, Wennerberg J, Alm P, von Eyben FE. Heterotransplantation of two human tumours in nude and asplenic-athymic mice. Acta Path Microbiol Immunol Scand (A) 1982;90:75-7
21. Mattsson W, von Eyben F, Hallsten L, Tennvall L. A trial of tamoxifen versus high-dose medroxyprogesterone acetate in advanced postmenopausal breast cancer. A final report. Excerpta Med Proc Int Symp Medroxyprogesterone Acetate, Geneva, Switzerland, February 24-26, 1982, Cavalli F, McGuire WL, Panutti F, Pellegrini A, Robustelli Della Guna G, eds, 1982;276-84
22. von Eyben FE, Skude G, Krabbe S. Serum lactate dehydrogenase and its isoenzymes in men with maldescended testes. J Urol 1982;128:1195-7
23. von Eyben FE, Skude G, Tropé C, Wennerberg J, Mikulowski P. Lactate dehydrogenase isoenzyme 1 (LDH-1) in athymic mice with xenografts of a human testicular germ cell tumor. MGG 1982;186:427-31
24. Berglund S, Eriksson M, von Eyben FE, Mattsson W, Hellekant C. Remission by chemotherapy of the Eaton-Lambert myasthenic syndrome in a patient with small cell bronchogenic carcinoma. Acta Med Scand 1982;212:429-32
25. von Eyben FE, Krag Jacobsen G, Pedersen H, Jacobsen M, Clausen PP, Cornelis Zibrandtsen P, Gullberg B. Multivariate analysis of risk factors in patients with metastatic testicular germ cell tumors treated with vinblastine and bleomycin. Invasion and Metastasis 1982;2:125-35(first multivariate analysis of risk factors for poor prognosis in patients with advanced testicular germ cell tumors, indicating a separate impact from S-LDH. Argues for the first time for a dichotomy in chemotherapy of patients with metastatic testicular germ cell tumors with an intensified therapy for poor prognosis patients. This approach is now standard all over the world.)
26. Borgström S, von Eyben FE, Flodgren P, Axelsson B, Sjögren HO. Human leukocyte interferon and cimetidine for metastatic melanoma. New Engl J Med 1982;307:1080-1 (widely cited paper (>100x) describing the tumoricidal effect of interferon for malignant melanoma. Today WHO studies have shown increased survival from adjuvant therapy with interferon in high risk patients after surgical resection of the primary malignant melanoma).
27. von Eyben FE. Lactate dehydrogenase and its isoenzymes in testicular germ cell tumors: an overview. Oncodevelopmental Biol Med 1983;4:395-414(thesis and personal review. Provides a recommendation for the routine use of S-LDH as a tumor marker of testicular germ cell tumors. The recommendation is part of the UICC TNM classification of 1997).
28. Skude G, von Eyben FE, Kristiansen P. Additional lactate dehydrogenase (LDH) isoenzymes in normal testis and spermatozoa of adult man. MGG 1984;198:172-4
29. von Eyben FE, Grann E, Dyrlund B. Xanthopsia treated with thiamine. Acta Ophthalm 1985;63:591-2 (zanthopsia as part of Wernicke's syndrome)
30. Flodgren P, Borgström S, von Eyben FE, Ingvar C, Jönsson PE, Malmström Å, Axelsson B, Sjögren HO. Metastatic malignant melanoma: regression induced by combined treatment with interferon (HUINF-alpha(Le)) and cimetidine. In: De Mayer E et al, eds.: The biology of the interferon system, 1983, TNO Congress, Rotterdam, The Netherlands 4/18-4/22 1983:499-504
31. Pugesgaard T, von Eyben FE. Bilateral optic neuritis evolved during tamoxifen treatment. Cancer 1986;58:383-6 (first description of a serious side effect of tamoxifen)
32. von Eyben FE, Høyer PE, Busch C. Microspectrophotometric observations of a microinvasive testicular germ cell tumor. In: Jones WG, Ward AM, Andersson CK, eds: Germ Cell Tumours II, Adv Biosci 1986;55:57-8
33. Siddiqui MZ, von Eyben FE, Spanos G. High-voltage irradiation and combination chemotherapy for malignant pheochromocytoma. Cancer 1988;62:686-90
34. Thunold S, von Eyben FE, Mæhle B. Malignant granular cell tumour of the neck: immunohistochemical and ultrastructural studies of a case. Histopathology 1989;14:655-7 (negates the existence of malignant myoblastoma)
35. von Eyben FE, Siddiqui MZ, Thunold S. Endodermal sinus tumor treated with high dose cisplatin. Acta Obstet Gynecol Scand 1989;68:669-70(first case of advanced ovarian germ cell tumor cured by third line high dose platinum combination chemotherapy followed by sequential courses of alternate drugs (time-intense therapy)).
36. von Eyben FE, Siddiqui MZ, Spanos G. High-voltage irradiation and hydroxyurea for pulmonary leukostasis in acute myelomonocytic leukemia. Acta Haemat 1987;77:180-2(described the complete regression of pulmonary leukostasis by irradiation -new treatment).
37. von Eyben FE, Blaabjerg O, Hyltoft Petersen P, Hørder M, Nielsen HV, Kruse-Andersen S, Parlev E. Serum lactate dehydrogenase isoenzyme as tumor marker in testicular germ cell tumor. J Urol 1988;140:986-90
38. von Eyben FE, Blaabjerg O, Hyltoft Petersen P, Hørder M, Nielsen HV, Kruse-Andersen S, Parlev E. Lactate dehydrogenase isoenzyme 1 in testis cancer. Lancet1987;ii:1035-6
39. Marckmann P, Højbjerg T, von Eyben FE, Christensen I. Imported pedal chancroid: case report. Genitourinary Med 1989;565:126-7
40. Pors H, von Eyben FE, Sørensen O, Larsen M. Longterm remission of multiple brain metastases with tamoxifen.J Neuro-oncology 1991;10:173-7
41. von Eyben FE, Blaabjerg O, Lindegaard-Madsen E, Hyltoft Petersen P, Smith-Sivertsen C, Gullberg B. Tumour volume and serum lactate dehydrogenase isoenzyme 1 are indicators of response to treatment and predictors of prognosis in advanced testicular germ cell tumours. Eur J Cancer 1992;28:410-5(describes S-LD-1 as a better tumor marker than S-LDH for patients with testicular germ cell tumors).
42. von Eyben FE, Grodum E, Gjessing HJ, Beck-Nielsen H, Hagen C. Metabolic remission with octreotide in patients with insulinoma. J Int Med 1993;
43. von Eyben FE, Blaabjerg O, Hyltoft Petersen P, MommsenS, Lindegaard-Madsen E, Kirkepar F, Li S S-L, Kristiansen K. Lactate dehydrogenase isoenzyme 1 (LDH-1) in testicular germ cell tumors. In: Oosterhuis JW, Walt H, Damjanov I, eds. Patho-biology of Human Germ Cell Neoplasia. Recent Results in Cancer Research 1991;123:85-92
44. von Eyben FE, de Grave W, Marrink J, Blaabjerg O, Sleijfer DT, Schraffordt Koops H, Oosterhuis JW, Hyltoft Petersen P, de Jong B. Serum lactate dehydrogenase isoenzyme 1 activity in patients with testicular germ cell tumors correlates to the total number of the short arm of chromosome 12 in the tumor. MGG 1992;235:140-6(describes S-LD-1 as reflecting a characteristic chromosomal abnormality in testicular germ cell tumors, isochromosome 12p).
45. Hansen PA, von Eyben FE, Gram J. Antithrombin III as part of treatment for a severe Leptospira Icterohaemorrhagiae infection. Submitted 1990
46. Ellekilde G, Holm J, von Eyben F, Hemmingsen L. Above- normal urinary excretion of albumin and retinol- binding protein in chronic heart failure. Clin Chem, 1992; 38: 593-4
47. Ellekilde G, Holm J, Hemmingsen L. Koczulab B, von Eyben FE. Impact of angiotensin-converting enzymes on urinary excretion of proteins in chronic heart failure. Clin Chem 1992;38:1377-8
48. von Eyben FE, Lindegaard Madsen E, Blaabjerg O, Hyltoft Petersen P. Lactate hydrogenase isoenzyme 1 as an early indicator of relapse patients with testicular germ cell tumors. Acta Oncologica 1995;34:925-9
49. von Eyben FE, Lindegaard Madsen E. Serum lactate dehydrogenase isoenzyme 1 as predictor of tumour-associated death in patients with testicular germ cell tumours. andrologia 1997;29:137-40.
50. Børger J, Zachau-Christensen J, von Eyben FE. Patientviden om egen medicin - belyst gennem struktureret interview af indlagte patienter. (Patient awareness of their own medication). Tidskrift for Dansk Sundhedsvæsen (J Danish Health Organisation) 1994;9:382-5
51. Feldager Hansen E, Tingsted Andersen L, von Eyben FE.Cigarette smoking and age at first acute myocardial infarction and influence of gender and extent of smoking. Am J Cardiol 1993;71:1439-41 (describes the higher risk from smoking for myocardial infarction in women compared with men. Cited by Braunwald in a 13 volume overview of the important facts in cardiology).
52. von Eyben FE, Hyltoft Petersen P, Blaabjerg O, Lindegaard Madsen E, Nørgaard Petersen B, Arends J. Correcting for contamination from hemolysis in measurements of lactate dehydrogenase isoenzyme 1 in serum from patients with testicular germ cell tumors. Clin Chem 1993;39:2199
53. von Eyben FE, Hyltoft Petersen P, Blaabjerg O, Lindegaard Madsen E, Nørgaard-Pedersen B, Arends J. Analytical bias by contamination from hemolysis indetermination of serum lactate dehydrogenase isoenzyme 1 in patients with testis germ cell tumors. Upsala J Med Sci 1993;98:293-8
54. Ellekilde G, von Eyben FE, Holm J, Hemmingsen L. Above-normal urinary excretion of albumin and retinol-binding protein for patients with acute myocardialinfarction. Clin Chem 1993;
55. von Eyben FE, Heerfordt J, Lassen JO, Jørgensen HP. Computertomografi i Grønland- basis for hjemtagelse. (Computer tomography in Greenland - the case for transferral of service). Ugeskr Læger 1994; 156: 4589-91
56. von Eyben FE, Bech J, Kyst Madsen J, Efsen F. High prevalence of smoking in young patients with acute myocardial infarction. J Roy Soc Health 1996;116:153-6
57. von Eyben FE. Planning arctic secondary andtertiary health care service. Congress book, IX Int Conf Circumpolar Health, Reykjavik, Iceland, in press 1994
58. von Eyben FE, Lindegaard Madsen E, Blaabjerg O, Hyltoft Petersen P, von der Maase H, Jacobsen GK, Rørth M. Serum lactate dehydrogenase isoenzyme 1 and relapse in patients from a randomized DATECA study of non-seminomatous testicular germ cell tumors clinical stage I -Surveillance alone after orchiectomy versus radiotherapy. Acta Oncologica, in press 2001.
59. ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group. ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58 050 patients with suspected acute myocardial infarction. Lancet 1995; 345: 669-85. (responsible for the trial at the Hospital in Lærdal, Norge)
60. von Eyben FE, von Eyben R. Smoking and other modifiable major coronary risk factors and acute myocardial infarction before 41 years of age. Two Danish case-control studies. In press, Scandinavian Cardiovascular Journal, 2000
61. von Eyben FE, Hyltoft Petersen P, Blaabjerg O, Lindegaard Madsen E. Analytical Quality Specifications for Serum Lactate Dehydrogenase Isoenzyme 1 Based on clinical Goals. Clinical Chemistry Laboratory Medicine, 1999;37:553-561
62. von Eyben FE, Thordal K. Avoidable deaths and screening for colorectal carcinoma. Gastroenterology, 1997;113:1422-4.
63. von Eyben FE. Smoking cessation as a rigorous primary intervention for coronary events in middle-aged men. A commentary based on the WOSCOP findings. Eur Heart J 1997;18:1187-9.
64. Byrialsen A, von Eyben FE, Kristiansen K. Carcinoma in situ of the testis and seminoma have high protein levels of lactate dehydrogenase (LD) subunit B and no LD subunit C. J Tumor Marker Oncology 1998;13:79-86.
65. von Eyben FE, Petersen PH, Blaabjerg O, Madsen EL. Analytical goals for monitoring serum lactate dehydrogenase isoenzyme 1 in patients with testicular germ cell tumors. In: Jones WG, Appleyard I, Harnden P, Joffe K, eds. Libbey & Co 1998;111-12.von Eyben FE, Liu FJ, Amato RJ, Fritsche HA. Serum lactate dehydrogenase isoenzyme 1 in patients with testicular germ cell tumors. Acta Oncologica 2000:39:509-17.
66. von Eyben FE, Madsen EL, Liu F, Amato R, Fritsche H. Serum lactate dehydrogenase isoenzyme 1 is a better prognostic predictor for metastatic testicular germ cell tumors than the TNM classification. J Tumor Marker Oncology, submitted, 2000.von Eyben FE. A systematic review of lactate dehydrogenase isoenzymes as tumor marker of germ cell tumors. Submitted Clin Biochem 2001.
67. von Eyben FE, Blaabjerg O, Petersen PH, Madsen EL, Amato R, Liu F, Fritsche H. Diagnostic performance of serum lactate dehydrogenase isoenzyme 1 in predicting death of tumor for patients with metastatic testicular germ cell tumors. CCLM 2001:39: 38-44.
68. von Eyben FE, Lindegaard Madsen E, Blaabjerg O, Pedersen B, Hyltoft Petersen P, Bent Nørgaard Pedersen, Lene Specht, Hans von der Maase. Serum lactate dehydrogenase isoenzyme 1 at orchiectomy in patients with seminoma stage I followed with surveillance. Acta Oncologica 2002; 41: 77-83.